Botanical species · safety record

Tussilago farfara

The EFSA Compendium of Botanicals holds 12 constituent measurements and 3 adverse-effect records for Tussilago farfara. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Tussilago farfara L.

12Constituent measurements

3Safety records

7Cited sources

107Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 107 licensed products naming Tussilago farfara as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Aerial parts
Dried flower buds
Flos
Flower
Flower buds
Fresh above ground parts
Leaf
Leaf/Leaves

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Pyrrolizidine alkaloids	Leaves	Solvent extraction	0.42 Microgram/gram	HPLC-DAD	Resolve DOI
Pyrrolizidine alkaloids	Leaves	Solvent extraction	55 Microgram/gram	GC-MS	Resolve DOI
Senecionine	Flower	Solvent extraction	0.02 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Senecionine	Leaves	Solvent extraction	0.23 Microgram/gram	HPLC-DAD	Resolve DOI
Senecionine-n-oxide	Flower	Solvent extraction	0.014 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Senkirkine	Flower	Solvent extraction	2.8 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Senkirkine	Flower	Solvent extraction	0.0075 Microgram/gram	LC-MS	Resolve DOI
Senkirkine	Leaves	Solvent extraction	0.19 Microgram/gram	HPLC-DAD	Resolve DOI
Tussilagine	Flower	Solvent extraction	—	LC-MS	Resolve DOI
Senecionine	Roots and other underground parts	Solvent extraction	1.4 ppm	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Senkirkine	Aerial part of plants	Solvent extraction	0.45 ppm	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Senkirkine	Roots and other underground parts	Solvent extraction	92.8 ppm	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Not stated	Digestive	Bud	Solvent extraction	—	In vitro	Resolve DOI
Not stated	Digestive	Bud	Solvent extraction	—	In vitro	Resolve DOI
Hepatotoxicity	Liver	—	—	House mouse (as animal)	Short-term toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Zhang, Yan., Huang, Fang., Wu, Di., Zhang, Mian. Hepatotoxicity of Flos Farfarae and contained alkaloid to mice. Shizhen guoyi guoyao, 2008, vol. 19, no. 8, p. 1810-1811.
Gao, Hong., Huang, Yi-Na., Gao, Bo., Xu, Pei-Yu., Inagaki, Chika., Kawabata, Jun. alpha-Glucosidase inhibitory effect by the flower buds of Tussilago farfara L. . Food chemistry, 2008, vol. 106, no. 3, p. 1195-1201. DOI
Adamczak, Artur., Opala, Bogna., Gryszczynska, Agnieszka., Buchwald, Waldemar. Content of pyrrolizidine alkaloids in the leaves of coltsfoot (Tussilago farfara L.) in Poland . Acta societatis botanicorum poloniae, 2013, vol. 82, no. 4, p. 289-293. DOI
Nedelcheva, Anely., Kostova, Nadezhda., Sidjimov, Atanas. Pyrrolizidine alkaloids in Tussilago farfara from Bulgaria. Biotechnology & biotechnological equipment, 2015, vol. 29, p. S1-S7. DOI
Avula, B., Sagi, S., Wang, Y.-H., Zweigenbaum, J., Wang, M., Khan, I.A. Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry. Food chemistry, 2015, vol. 178, p. 136-148. DOI
Mroczek, Tomasz., Glowniak, Kazimierz., Wlaszczyk, Anna. Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase extraction and ion-pair high-performance liquid chromatography. Journal of chromatography a, 2002, vol. 949(1-2), p. 249-262.
Smyrska-Wieleba, Natalia., Wojtanowski, Krzysztof Kamil., Mroczek, Tomasz. Comparative HILIC/ESI-QTOF-MS and HPTLC studies of pyrrolizidine alkaloids in flowers of Tussilago farfara and roots of Arnebia euchroma . Phytochemistry letters, 2017, vol. 20, p. 339-349. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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