Botanical species · safety record

Uncaria rhynchophylla

The EFSA Compendium of Botanicals holds 14 constituent measurements and 1 adverse-effect record for Uncaria rhynchophylla. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Uncaria rhynchophylla (Miq.) Miq. ex Havil.

14Constituent measurements

1Safety records

8Cited sources

130Licensed products (Canada)

Also recorded as

Nauclea rhynchophylla Miq.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 130 licensed products naming Uncaria rhynchophylla as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
decoction

Source material stated

Branch
Branch Leafy
Branch(es)
Branchlet
Dried hook-bearing branch
Hook-bearing branch
Hooked Twigs
New material

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
(+)-pulegone	Stem / stalk	Essential oil	2.5 Percent Area	GC-MS	Resolve DOI
1,8-cineole	Stem / stalk	Essential oil	1 Percent Area	GC-MS	Resolve DOI
Alkaloids	Stem / stalk	Solvent extraction	0.358 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Cinnamaldehyde	Stem / stalk	Essential oil	13.4 Percent Area	GC-MS	Resolve DOI
Estragole	Stem / stalk	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Indole alkaloids	Unspecified	—	—	Unspecified	Resolve DOI
Menthone	Stem / stalk	Essential oil	1 Percent Area	GC-MS	Resolve DOI
Methyleugenol	Stem / stalk	Essential oil	6.8 Percent Area	GC-MS	Resolve DOI
Myristicin	Stem / stalk	Essential oil	2 Percent Area	GC-MS	Resolve DOI
Safrole	Stem / stalk	Essential oil	2.2 Percent Area	GC-MS	Resolve DOI
Alkaloids	Unspecified	—	0.207 Percent	UV/VIS spectroscopy (photometry)	No resolvable identifier
Harman	Stem / stalk	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Indole alkaloids	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Indole alkaloids	Stem / stalk	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Unspecified	—	Rat (as animal)	Short-term toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Yang, Zhongduo., Zhang, Dongbo., Ren, Jin., Yang, Mingjun., Li, Shuo. Acetylcholinesterase inhibitory activity of the total alkaloid from traditional Chinese herbal medicine for treating Alzheimer's disease . Medicinal chemistry research, 2012, vol. 21, no. 6, p. 734-738. DOI
Shin, Suk-Chul., Lee, Dong-Ung. Ameliorating effect of new constituents from the hooks of Uncaria rhynchophylla on scopolamine-induced memory impairment. CHINESE JOURNAL OF NATURAL MEDICINES, 2013, vol. 11, no. 4, p. 391-395. DOI
Iwasa, Megumi., Nakaya, Satoshi., Maki, Yusuke., Marumoto, Shinsuke., Usami, Atsushi., Miyazawa, Mitsuo. Identification of Aroma-active Compounds in Essential Oil from Uncaria Hook by Gas Chromatography-Mass Spectrometry and Gas Chromatography-Olfactometry. JOURNAL OF OLEO SCIENCE, 2015, vol. 64, no. 8, p. 825-833. DOI
Mo, Zhixian., Yan, Yumiao., Zhou, Xiaojun., Chen, Wenqian., Chen, Yifei. Content determination of total alkaloids in Uncaria rhynchophylloides how and its pharmacological actions. Shizhen guoyi guoyao, 2011, p. 1037-1039.
Liu, Wei., Wang, Zhong-shi., Zhang, Hui., Zhang, Xu., Jiang, Xiao-ling., Gao, Yun-sheng. Hepatotoxicity of oral Uncaria rhynchophylla total alkaloids to hypertensive rats. Zhongguo yaolixue tongbao, 2014, p. 883-884.
Haginiwa, Joju., Sakai, Shinichiro., Aimi, Norio., Yamanaka, Etsuji., Shinma, Nobuo. Plants containing indole alkaloids. 2. Alkaloids of Uncaria rhynchophylla. Yakugaku Zasshi, 1973, p. 448-452.
Masumiya, H., Saitoh, T., Tanaka, Y., Horie, S., Aimi, N., Takayama, H., Tanaka, H., Shigenobu, K. Effects of hirsutine and dihydrocorynantheine om the action potentials of sino-atrial node, atrium and ventricle . Life sciences, 1999, vol. 65, no. 22, p. 2333-2341. DOI
Hong1, Seong Su., So Young Park1., Jai Seup Ro1, *., Hur3, Jae Doo., Han1, Xiang Hua., Woo Hoi Choi1., Bang Yeon Hwang1., Myung Koo Lee1, 2,. Monoamine Oxidase Inhibitor from Uncaria rhynchophylla. Natural Product Sciences, 2005, vol. 11, no. 3, p. 145-149.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature