Botanical species · safety record

Uncaria tomentosa

The EFSA Compendium of Botanicals holds 4 constituent measurements and 3 adverse-effect records for Uncaria tomentosa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Uncaria tomentosa (Willd. ex Schult.) DC.

4Constituent measurements

3Safety records

5Cited sources

190Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 190 licensed products naming Uncaria tomentosa as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA

Source material stated

Aged bark
Bark
Bark (powder)
Bark and roots
Bark extract
Branch
Branch bark
Herb

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Indole alkaloids	Bark	Solvent extraction	—	GC-MS	Resolve DOI
Indole alkaloids	Bark	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Indole alkaloids	Bark	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Tannins	Bark	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Nephrotoxicity	Urogenital: kidneys	Unspecified	—	Human (as organism)	Case report	Resolve DOI
Teratogenic	Muscle, skeletal	Unspecified	—	House mouse (as animal)	Reproduction toxicity	No resolvable identifier
Teratogenic	Muscle, skeletal	Unspecified	—	House mouse (as animal)	Reproduction toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Garcia Gimenez, Dolores., Garcia Prado, Elena., Saenz Rodriguez, Teresa., Fernandez Arche, Angeles., De la Puerta, Rocio. Cytotoxic Effect of the Pentacyclic Oxindole Alkaloid Mitraphylline Isolated from Uncaria tomentosa Bark on Human Ewing's Sarcoma and Breast Cancer Cell Lines . Planta medica, 2010, vol. 76, no. 2, p. 133-136. DOI
Kuras, Mieczyslaw., Pilarski, Radoslaw., Nowakowska, Julita., Zobel, Alicja., Brzost, Krzysztof., Antosiewicz, Justyna., Gulewicz, Krzysztof. Effect of Alkaloid-Free and Alkaloid-Rich preparations from Uncaria tomentosa bark on mitotic activity and chromosome morphology evaluated by Allium Test. JOURNAL OF ETHNOPHARMACOLOGY, 2009, vol. 121, no. 1, p. 140-147. DOI
Pilarski, Radoslaw., Filip, Beata., Wietrzyk, Joanna., Kuras, Mieczyslaw., Gulewicz, Krzysztof. Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition . Phytomedicine, 2010, vol. 17, no. 14, p. 1133-1139. DOI
Steenkamp, V., Stewart, M.J. Nephrotoxicity associated with exposure to plant toxins, with particular reference to Africa. Therapeutic drug monitoring, 2005, vol. 27, no. 3, p. 270-277. DOI
Iziga, R., Gutierrez-Pajares, J., Pino, J. In vivo effect of Uncaria tomentosa (Willd.) D C. (Rubiaceae) Cat's claw on the 72 h.p.c. preimplantation mouse embryo development . Boletin de la sociedad de biologia de concepcion, 1998, vol. 69, no. 0, p. 141-145.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature