Botanical species · safety record

Veratrum album

The EFSA Compendium of Botanicals holds 4 constituent measurements and 8 adverse-effect records for Veratrum album. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Veratrum album L.

4Constituent measurements

8Safety records

6Cited sources

100Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 100 licensed products naming Veratrum album as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Adherent roots
Broken and dried underground parts
Carefully dried rhizomes
Dried rhizome
Dried rhizome and adherent roots
Dried root(s)
Dried underground parts
Fresh aerial part collected at flowering time

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Cyclopamine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Cevadine	Seed	—	0.023 Percent	LC-MS	No resolvable identifier
Veratridine	Seed	—	0.126 Percent	LC-MS	No resolvable identifier
Veratrum alkaloids	Roots and other underground parts	Solvent extraction	—	LC-MS-MS (QqQ)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Roots and other underground parts	—	Human (as organism)	Case report	Resolve DOI
Neurotoxicity	Neurologic	Leaves	—	Human (as organism)	Case report	Resolve DOI
Other toxicities	Digestive	Leaves	—	Human (as organism)	Case report	Resolve DOI
Other toxicities	—	Roots and other underground parts	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Cardiovascular / haematological	Leaves	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Heart	Roots and other underground parts	—	Human (as organism)	Case report	Resolve DOI
Other toxicities	—	Seed	—	Human (as organism)	Case report	No resolvable identifier
Other toxicities	—	Roots and other underground parts	—	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Gaillard, Y., Pepin, G. LC-EI-MS determination of veratridine and cevadine in two fatal cases of Veratrum album poisoning . Journal of analytical toxicology, 2001, vol. 25, no. 6, p. 481-485.
Gilotta, Irene., Brvar, Miran. Accidental poisoning with Veratrum album mistaken for wild garlic (Allium ursinum) . Clinical toxicology, 2010, vol. 48, no. 9, p. 949-952. DOI
Grobosch, T., Binscheck, T., Martens, F., Lampe, D. Accidental Intoxication with Veratrum album. Journal of analytical toxicology, 2008, vol. 32, no. 9, p. 768-773.
Rauber-Luethy, Christine., Halbsguth, Ulrike., Kupferschmidt, Hugo., Koenig, Naoko., Megevand, Chloe., Zihlmann, Karin., Ceschi, Alessandro. Low-dose exposure to Veratrum album in children causes mild effects - a case series . Clinical toxicology, 2010, vol. 48, no. 3, p. 234-237. DOI
Zagler, B., Zelger, A., Salvatore, C., Pechlaner, C., De Giorgi, F., Wiedermann, CJ. Dietary poisoning with Veratrum album - A report of two cases. Wiener klinische wochenschrift, 2005, vol. 117, no. 3, p. 106-108. DOI
Wilson, Steven Ray., Strand, Martin Frank., Krapp, Andreas., Rise, Frode., Herstad, Gunnar., Malterud, Karl Egil., Krauss, Stefan. Hedgehog antagonists cyclopamine and dihydroveratramine can be mistaken for each other in Veratrum album . Journal of pharmaceutical and biomedical analysis, 2010, vol. 53, no. 3, p. 497-502. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature