Botanical species · safety record

Veratrum californicum

The EFSA Compendium of Botanicals holds 5 constituent measurements and 4 adverse-effect records for Veratrum californicum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Veratrum californicum Durand

5Constituent measurements

4Safety records

6Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Cyclopamine	Roots and other underground parts	Solvent extraction	—	UHPLC-MS-MS	Resolve DOI
Cycloposine	Unspecified	Solvent extraction	4 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Cyclopamine	Roots and other underground parts	Solvent extraction	6 Gram/kilogram	UHPLC-MS-MS	No resolvable identifier
Cycloposine	Roots and other underground parts	Solvent extraction	6 Gram/kilogram	UHPLC-MS-MS	No resolvable identifier
Steroidal alkaloids	Roots and other underground parts	Solvent extraction	—	UHPLC-MS-MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Teratogenic	Muscle, skeletal	Roots and other underground parts	Solvent extraction	Sheep (as animal)	Reproduction toxicity	Resolve DOI
Teratogenic	Muscle, skeletal	—	—	Sheep (as animal)	Case report	No resolvable identifier
Teratogenic	Muscle, skeletal	—	—	Hamster (as animal)	Reproduction toxicity	No resolvable identifier
Teratogenic	Spinal cord	Unspecified	—	Cattle (as animal)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

JAMES, LF., PANTER, KE., NIELSEN, DB., MOLYNEUX, RJ. THE EFFECT OF NATURAL TOXINS ON REPRODUCTION IN LIVESTOCK. Journal of animal science, 1992, vol. 70, no. 5, p. 1573-1579.
Chandler, Christopher M., Habig, Jeffrey W., Fisher, Ashley A., Ambrose, Katherine V., Jimenez, Susana T., McDougal, Owen M. Improved Extraction and Complete Mass Spectral Characterization of Steroidal Alkaloids from Veratrum californicum . Natural product communications, 2013, vol. 8, no. 8, p. 1059-1064.
KEELER, RF. TERATOGENIC COMPOUNDS OF VERATRUM CALIFORNICUM (DURAND) .7. STRUCTURE OF GLYCOSIDIC ALKALOID CYCLOPOSINE . Steroids, 1969, vol. 13, no. 5, p. 579-&. DOI
Welch, K. D., Panter, K. E., Lee, S. T., Gardner, D. R., Stegelmeier, B. L., Cook, D. Cyclopamine-induced synophthalmia in sheep: defining a critical window and toxicokinetic evaluation . Journal of applied toxicology, 2009, vol. 29, no. 5, p. 414-421. DOI
Coventry-, S., Kapur, R.P., Siebert, J.R. Holoprosencephalic facies induced in golden hamsters by the teratogen cyclopamine. Pediatric pathology and laboratory medicine, 1996, vol. 16, no. 2, p. 351-352.
Leipold, H.W., Husby, F., Brundage, A.L., Shupe, J.L. Congenital defects of calves on Kodiak Island. Journal of the american veterinary medical association, 1977, vol. 170, no. 12, p. 1408-1410.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature