Botanical species · safety record

Veratrum viride

The EFSA Compendium of Botanicals holds 6 constituent measurements and 4 adverse-effect records for Veratrum viride. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Veratrum viride Aiton

6Constituent measurements

4Safety records

9Cited sources

23Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 23 licensed products naming Veratrum viride as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Root
Tincture of the root

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Steroidal alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Steroidal alkaloids	Aerial part of plants	Solvent extraction	—	GC-MS	Resolve DOI
Jervine	Unspecified	Solvent extraction	—	—	No resolvable identifier
Steroidal alkaloids	Roots and other underground parts	Solvent extraction	—	—	No resolvable identifier
Steroidal alkaloids	Unspecified	Solvent extraction	—	—	No resolvable identifier
Steroidal alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Heart	—	—	Human (as organism)	Case report	Resolve DOI
Neurotoxicity	Heart	Unspecified	—	Human (as organism)	Case report	Resolve DOI
Neurotoxicity	Heart	Leaves	—	—	Case report	Resolve DOI
Teratogenic	Muscle, skeletal	—	—	House mouse (as animal)	Reproduction toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Forrester, Joseph D., Price, Justin H., Holstege, Christopher P. Intoxication With a Ramp (Allium tricocca) Mimicker. Wilderness & environmental medicine, 2010, vol. 21, no. 1, p. 61-63. DOI
NEWMAN, AJ. INTOXICATION WITH VERATRUM VIRIDE. Journal of pediatrics, 1952, vol. 40, no. 2, p. 233-234. DOI
Omnell, M.L., Sim, F.R.P., Keeler, R.F., Harne, L.C., Brown, K.S. Expression of Veratrum alkaloid teratogenicity in the mouse. Teratology, 1990, vol. 42, no. 2, p. 105-119. DOI
ELSAYED, KA., MCCHESNEY, JD., HALIM, AF., ZAGHLOUL, AM., VOEHLER, M. 2 STEROIDAL ALKALOIDS FROM VERATRUM-VIRIDE. Phytochemistry, 1995, vol. 38, no. 6, p. 1547-1550. DOI
Jacobs, Walter A., Craig, Lyman C. Veratrine alkaloids. XXII. On pseudojervine and veratrosine, a companion glycoside in Veratrum viride. Journal of biological chemistry, 1944, vol. 155, p. 565-72.
Seiferle, E. J., Johns, I. B., Richardson, C. H. Alkaloids of American hellebore and their toxicity to the American cockroach. Journal of economic entomology, 1942, vol. 35, p. 35-44.
ElSayed, KA., McChesney, JD., Halim, HF., Zaghloul, AM., Lee, IS. A study of alkaloids in Veratrum viride Aiton. International journal of pharmacognosy, 1996, vol. 34, no. 3, p. 161-173.
Bechtel, L. K., Lawrence, D. T., Haverstick, D., Powers, J. S., Wyatt, S. A., Croley, T., Holstege, C. P. Ingestion of false hellebore plants can cross-react with a digoxin clinical chemistry assay . Clinical toxicology, 2010, vol. 48, no. 5, p. 435-442. DOI
Jaffe, A M., Gephardt, D., Courtemanche, L. Poisoning due to ingestion of Veratrum viride (false hellebore).. The journal of emergency medicine, 1990, vol. 8, no. 2, p. 161-7. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature