Botanical species · safety record

Vicia sativa

The EFSA Compendium of Botanicals holds 13 constituent measurements and 8 adverse-effect records for Vicia sativa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Vicia sativa L.

13Constituent measurements

8Safety records

8Cited sources

0Licensed products (Canada)

Also recorded as

Vicia angustifolia L.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Beta-cyano-l-alanine	Seed	—	0.93 Percent	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Beta-cyano-l-alanine	Seed	Solvent extraction	≥ 0.01 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Beta-cyano-l-alanine	Seed	Solvent extraction	≤ 0.03 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Cyanogenic glycosides	Seed	Solvent extraction	—	HPLC-DAD	Resolve DOI
Ethanolamine	Leaves	Solvent extraction	6.6 Microgram/gram	HPLC-DAD	Resolve DOI
Gamma-glutamyl-beta-cyanoalanine	Seed	Solvent extraction	≥ 0.42 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Gamma-glutamyl-beta-cyanoalanine	Seed	Solvent extraction	≤ 0.74 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Vicianin	Seed	—	—	—	Resolve DOI
4-amino-butyric acid	Seed	Solvent extraction	—	—	No resolvable identifier
Alkaloids	Seed	Raw, no heat treatment	—	Unspecified	No resolvable identifier
Beta-cyano-l-alanine	Seed	Solvent extraction	≥ 0.09 Percent	UV/VIS spectroscopy (photometry)	No resolvable identifier
Beta-cyano-l-alanine	Seed	Solvent extraction	≤ 0.15 Percent	UV/VIS spectroscopy (photometry)	No resolvable identifier
Hydrocyanic acid	Seed	Raw, no heat treatment	64.8 Milligram/100 gram	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Reproductive	Urogenital	Live plants	—	Cattle (as animal)	Case report	Resolve DOI
Systemic	—	Seed	—	Gallus gallus (chicken) (as animal)	Short-term toxicity	Resolve DOI
Hepatotoxicity	Liver	Live plants	—	Horse (as animal)	Case report	No resolvable identifier
Hepatotoxicity	Liver	Live plants	—	Pig (as animal)	Case report	No resolvable identifier
Neurotoxicity	Neurologic	—	—	Rat (as animal)	Acute toxicity	No resolvable identifier
Neurotoxicity	Neurologic	Seed	—	Rhesus monkey (as animal)	Not reported	No resolvable identifier
Neurotoxicity	Neurologic	Seed	—	Duck (as animal)	Not reported	No resolvable identifier
Systemic	—	Seed	Raw, no heat treatment	Rabbit (as animal)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Ressler, C., Tatake, JG., Kaizer, E., Putnam, DH. Neurotoxins in a vetch food: Stability to cooking and removal of gamma-glutamyl-beta-cyanoalanine and beta-cyanoalanine and acute toxicity from common vetch (Vicia sativa L) legumes . Journal of agricultural and food chemistry, 1997, vol. 45, no. 1, p. 189-194. DOI
Steyn, D. G. Poisoning of human beings by weeds contained in cereals (bread poisoning). Onderstepoort journal of veterinary research, 1933, vol. 1, p. 219-66.
Suter, RJ. Suspected cyanide poisoning in cows fed vetch (Vicia sativa) hay. Australian veterinary journal, 2002, vol. 80, no. 5, p. 282-282. DOI
RESSLER, C. ISOLATION AND IDENTIFICATION FROM COMMON VETCH OF NEUROTOXIN BETA-CYANO-L-ALANINE, A POSSIBLE FACTOR IN NEUROLATHYRISM . Journal of biological chemistry, 1962, vol. 237, no. 3, p. 733-&.
Ahn, Young Ock., Saino, Hiromichi., Mizutani, Masaharu., Shimizu, Bun-ichi., Sakata, Kanzo. Vicianin hydrolase is a novel cyanogenic beta-glycosidase specific to beta-vicianoside (6-O-alpha-l-arabinopyranosyl-beta-d-glucopyranoside) in seeds of Vicia angustifolia . Plant and cell physiology, 2007, vol. 48, no. 7, p. 938-947. DOI
Berger, JD., Robertson, LD., Cocks, PS. Agricultural potential of Mediterranean grain and forage legumes: 2) Anti-nutritional factor concentrations in the genus Vicia . Genetic resources and crop evolution, 2003, vol. 50, no. 2, p. 201-212. DOI
Ressler, C., Tatake, JG. Vicianin, prunasin, and beta-cyanoalanine in common vetch seed as sources of urinary thiocyanate in the rat . Journal of agricultural and food chemistry, 2001, vol. 49, no. 10, p. 5075-5080. DOI
Kamo, Tsunashi., Tokuoka, Yoshinori., Miyazaki, Masahisa. Quantification of Canavanine, 2-Aminoethanol, and Cyanamide in Aphis craccivora and its Host Plants, Robinia pseudoacacia and Vicia angustifolia: Effects of These Compounds on Larval Survivorship of Harmonia axyridis . Journal of chemical ecology, 2012, vol. 38, no. 12, p. 1552-1560. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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