Botanical species · safety record

Vitex agnus-castus

The EFSA Compendium of Botanicals holds 25 constituent measurements and 6 adverse-effect records for Vitex agnus-castus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Vitex agnus-castus L.

25Constituent measurements

6Safety records

8Cited sources

755Licensed products (Canada)

Also recorded as

Vitex pseudonegundo (Hausskn.) Hand.-Mazz.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 755 licensed products naming Vitex agnus-castus as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
fluid

Source material stated

Berries
Berry extract
Berry/Berries
Dried fruit
Flower
Fruit
Fruit (berry)
Fruit (standardized extract)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
(-)-globulol	Aerial part of plants	Essential oil	≤ 1.8 Percent	GC-FID	Resolve DOI
(-)-globulol	Aerial part of plants	Essential oil	≤ 2.1 Percent	GC-MS	Resolve DOI
(-)-globulol	Aerial part of plants	Essential oil	≥ 1.2 Percent	GC-MS	Resolve DOI
1,8-cineole	Leaves	Essential oil	19.46 Percent	GC-MS	Resolve DOI
1,8-cineole	Fruit unspecified	Essential oil	18.2 Percent	GC-FID	Resolve DOI
1,8-cineole	Flower	Essential oil	1.5 Percent	GC-MS	Resolve DOI
4-hydroxybenzoic acid	Fruit unspecified	Solvent extraction	15 Milligram	GC-MS	Resolve DOI
4-hydroxybenzoic acid	Fruit unspecified	Solvent extraction	125 Milligram	GC-MS	Resolve DOI
Dillapiole	Fruit unspecified	Essential oil	1 Percent	GC-MS	Resolve DOI
Diterpenes	Fruit unspecified	Essential oil	≤ 1.2 Percent	GC-FID	Resolve DOI
Labdane diterpenes	Fruit unspecified	Solvent extraction	6 Milligram	GC-MS	Resolve DOI
Labdane diterpenes	Fruit unspecified	Solvent extraction	11 Milligram	GC-MS	Resolve DOI
Labdane diterpenes	Fruit unspecified	Solvent extraction	4 Milligram	GC-MS	Resolve DOI
Labdane diterpenes	Fruit unspecified	Solvent extraction	40 Milligram	GC-MS	Resolve DOI
Labdane diterpenes	Fruit unspecified	Solvent extraction	25 Milligram	GC-MS	Resolve DOI
Labdane diterpenes	Fruit unspecified	Solvent extraction	14 Milligram	GC-MS	Resolve DOI
Labdane diterpenes	Fruit unspecified	Solvent extraction	67 Milligram	GC-MS	Resolve DOI
Myrcene	Leaves	Essential oil	1.63 Percent	GC-MS	Resolve DOI
Myrcene	Fruit unspecified	Essential oil	2.7 Percent	GC-FID	Resolve DOI
Alkaloids	Live plants	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Beta-eudesmol	Leaves	Essential oil	1.42 Percent	GC-MS	No resolvable identifier
Beta-selinene	Leaves	Essential oil	1.44 Percent	GC-MS	No resolvable identifier
Eugenol	Leaves	Essential oil	1.71 Percent	GC-MS	No resolvable identifier
Myrcene	Leaves	Essential oil	1.49 Percent	GC-MS	No resolvable identifier
Saponins	Live plants	Solvent extraction	—	Phytochemical screening	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Fruit unspecified	Solvent extraction	Human (as organism)	Other	Resolve DOI
Hepatotoxicity	Liver	Fruit unspecified	Solvent extraction	Human (as organism)	Other	Resolve DOI
Immunotoxicity	Skin/subcutis	Fruit unspecified	Solvent extraction	Human (as organism)	Other	Resolve DOI
Neurotoxicity	Neurologic	Fruit unspecified	Solvent extraction	Human (as organism)	Other	Resolve DOI
Pulmonary and cardiac	Heart	Fruit unspecified	Solvent extraction	Human (as organism)	Other	Resolve DOI
Reproductive	Uterus	Fruit unspecified	Solvent extraction	Human (as organism)	Other	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Di Lorenzo, Chiara., Ceschi, Alessandro., Kupferschmidt, Hugo., Luede, Saskia., Nascimento, Elizabeth De Souza., Dos Santos, Ariana., Colombo, Francesca., Frigerio, Gianfranco., Norby, Karin., Plumb, Jenny., Finglas, Paul., Restani, Patrizia. Adverse effects of plant food supplements and botanical preparations: a systematic review with critical evaluation of causality . British journal of clinical pharmacology, 2015, vol. 79, no. 4, p. 578-592. DOI
Khalilzadeh, Emad., Saiah, Gholamreza Vafaei., Hasannejad, Hamideh., Ghaderi, Adel., Ghaderi, Shahla., Hamidian, Gholamreza., Mahmoudi, Razzagh., Eshgi, Davoud., Zangisheh, Mahsa. Antinociceptive effects, acute toxicity and chemical composition of Vitex agnus-castus essential oil . Avicenna journal of phytomedicine, 2015, vol. 5, no. 3, p. 218-230.
Aynehchi, Y., Sormaghi, M. H. Salehi., Amin, G. H., Soltani, A., Qumehr, N. Survey of Iranian plants for saponins, alkaloids, flavonoids and tannins. II. International journal of crude drug research, 1982, vol. 20, no. 1, p. 61-70.
Li, Shenghong., Qiu, Shengxiang., Yao, Ping., Sun, Handong., Fong, Harry H. S., Zhang, Hongjie. Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction . Evidence-based complementary and alternative medicine, 2013. DOI
Borzoui, Ehsan., Naseri, Bahram., Abedi, Zahra., Karimi-Pormehr, Mohammad Sadegh. Lethal and Sublethal Effects of Essential Oils From Artemisia khorassanica and Vitex pseudo-negundo Against Plodia interpunctella (Lepidoptera: Pyralidae) . Environmental entomology, 2016, vol. 45, no. 5, p. 1220-1226. DOI
Duymus, H. G., Ciftci, G. Akalin., Yildirim, S. Ulusoylar., Demirci, B., Kirimer, N. The cytotoxic activity of Vitex agnus castus L. essential oils and their biochemical mechanisms . Industrial crops and products, 2014, vol. 55, p. 33-42. DOI
Neves, Roberta C. S., Da Camara, Claudio A. G. Chemical composition and acaricidal activity of the essential oils from Vitex agnus-castus L. (Verbenaceae) and selected monoterpenes . Anais da academia brasileira de ciencias, 2016, vol. 88, no. 3, p. 1221-1233. DOI
Novak, J., Draxler, L., Gohler, I., Franz, CM. Essential oil composition of Vitex agnus-castus - comparison of accessions and different plant organs . Flavour and fragrance journal, 2005, vol. 20, no. 2, p. 186-192. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature