Botanical species · safety record

Vitex negundo

The EFSA Compendium of Botanicals holds 21 constituent measurements and 2 adverse-effect records for Vitex negundo. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Vitex negundo L.

21Constituent measurements

2Safety records

11Cited sources

12Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 12 licensed products naming Vitex negundo as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Fruit
Leaf
Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Unspecified	Solvent extraction	0.86 Percent	Phytochemical screening	Resolve DOI
Lignans	Seed	Solvent extraction	—	Chromatographic tests	Resolve DOI
Saponins	Unspecified	Solvent extraction	3.03 Percent	Phytochemical screening	Resolve DOI
Tannins	Unspecified	Solvent extraction	9.39 Percent	Phytochemical screening	Resolve DOI
1,8-cineole	Live plants	Essential oil	—	—	No resolvable identifier
1,8-cineole	Leaves	Essential oil	≥ 0.03 Percent	GC-FID-MS	No resolvable identifier
1,8-cineole	Flower	Essential oil	5.5 Percent	GC-MS	No resolvable identifier
1,8-cineole	Leaves	Essential oil	≤ 1.43 Percent	GC-FID-MS	No resolvable identifier
1,8-cineole	Leaves	Essential oil	1.33 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
1,8-cineole	Leaves	Essential oil	—	Unspecified	No resolvable identifier
Alkaloids	Seed	Solvent extraction	—	Unspecified	No resolvable identifier
Camphor	Leaves	Essential oil	≤ 1.44 Percent	GC-FID-MS	No resolvable identifier
Camphor	Leaves	Essential oil	—	Unspecified	No resolvable identifier
Camphor	Leaves	Essential oil	0.96 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Camphor	Leaves	Essential oil	≥ 0.42 Percent	GC-FID-MS	No resolvable identifier
Epoxides	Live plants	Essential oil	—	Unspecified	No resolvable identifier
Epoxides	Fruit unspecified	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Eugenol	Leaves	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Furanocoumarins	Fruit unspecified	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Myrcene	Leaves	Essential oil	≤ 1.33 Percent	GC-FID-MS	No resolvable identifier
Myrcene	Leaves	Essential oil	≥ 0.42 Percent	GC-FID-MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Reproductive	Testes	Seed	Powder	Human (as organism)	Reproduction toxicity	No resolvable identifier
Reproductive	Testes	Seed	Powder	Human (as organism)	Reproduction toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Jirovetz, Leopold., Buchbauer, Gerhard., Puschmann, Christiane., Shafi, Mohamed P., Nambiar, M. K. Geetha. Analysis of the essential oils of the leaves of medicinal plants Vitex negundo var. negundo and Vitex negundo var. purpurescens from India . Acta pharmaceutica (zagreb), 1998, vol. 48, no. 3, p. 179-186.
Zhou, YingJun., Liu, Yiliang Ellie., Cao, JianGuo., Zeng, GuangYao., Shen, Cui., Li, YanLan., Zhou, MeiChen., Chen, Yiding., Pu, Weiping., Potters, Louis., Shi, Y. Eric. Vitexins, Nature-Derived Lignan Compounds, Induce Apoptosis and Suppress Tumor Growth . Clinical cancer research, 2009, vol. 15, no. 16, p. 5161-5169. DOI
Khan, Amir Muhammad., Qureshi, Rizwana Aleem., Ullah, Faizan., Gilani, Syed Aneel., Nosheen, Asia., Sahreen, Sumaira., Laghari, Muhammad Khan., Laghari, Muhammad Yousif., Shafiq-Ur-Rehman., Hussain, Ishtiaq., Murad, Waheed. Phytochemical analysis of selected medicinal plants of Margalla Hills and surroundings. JOURNAL OF MEDICINAL PLANTS RESEARCH, 2011, vol. 5, no. 25, p. 6017-6023. DOI
Sun, Lingfeng. Chemical constituents of essential oil from Vitex negundo L. var. cannabifolia (Sieb. et Zucc.) Hand. -Mazz. Linchan huaxue yu gongye, 1989, p. 42-47.
Yadav, Hemendra., Mungara, Pankaj., Jivrajani, Mehul., Nivsarkar, Manish., Anandjiwala, Sheetal. TLC-DENSITOMETRIC QUANTIFICATION OF NEGUNDOSIDE, URSOLIC ACID, EUGENOL, LUPEOL, AND beta-SITOSTEROL USING HPTLC FROM VITEX NEGUNDO LEAVES. Journal of Liquid Chromatography Related Technologies, 2012, p. 1565-1584.
Zhao, X.-X., Zheng, C.-J., Qin, L.-P. Chemical constituents from fruits of Vitex negundo. Chinese traditional and herbal drugs, 2012, vol. 43, no. 12, p. 2346-2350.
Liu Yu-qing., Xue Ming., Zhou Fang-yuan., Xu Hua-qiang. Toxicity of total alkaloids from Vitex negundo seeds against apterous adults of Aphis gossypii and its effect on activity of some enzymes . Journal of plant resources and environment, 2011, vol. 20, no. 3, p. 43-50.
Rai, R., Nath, V. Some lesser known oral herbal contraceptives in folk claims as anti-fertility and fertility induced plants in Bastar region of Chhattisgarh. Journal of Natural Remedies, 2005, vol. 5, no. 2, p. 153-159.
Zhang, Shu-feng., Dong, Qing-feng., Yu, Xin-rui., Hu, Cong., Qin, Kui., Qu, Lei., Hao, Yong. Chemical composition of aborted flower essential oil of vitex negundo var. heterophylla growing wild in shijiazhuang. Tianran chanwu yanjiu yu kaifa, 2014, p. 883-885.
Taneja, S. C., Gupta, R. K., Dhar, K. L., Atal, C. K. The essential oil of Vitex negundo Linn. Indian perfumer, 1979, p. 162-163.
Dayal, Rameshwar., Singh, Virendra. A comparative study of volatile constituents of Vitex negundo leaves. Journal of medicinal and aromatic plant sciences, 2000, vol. 22, no. 1B, p. 639-640.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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