Botanical species · safety record

Vitis vinifera

The EFSA Compendium of Botanicals holds 3 constituent measurements, 1 adverse-effect record and 1 genotoxicity assay for Vitis vinifera. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Vitis vinifera L.

3Constituent measurements

2Safety records

4Cited sources

2,525Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 2,525 licensed products naming Vitis vinifera as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
fluid
solid

Source material stated

Blueberry
Buds
Dried fruit
Dried seed
Edible fruit part
Florets
Flower
Flower clusters

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Gallic acid	Fruit unspecified	Solvent extraction	≤ 1.57 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Gallic acid	Fruit unspecified	Solvent extraction	≥ 0.22 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Proanthocyanidins (condensed tannins)	Seed	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Systemic	—	Seed	Fresh	Dog (as animal)	Case report	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	With and without	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Lluis, Laura., Munoz, Monica., Rosa Nogues, M., Sanchez-Martos, Vanessa., Romeu, Marta., Giralt, Montse., Valls, Josep., Sola, Rosa. Toxicology evaluation of a procyanidin-rich extract from grape skins and seeds . Food and chemical toxicology, 2011, vol. 49, no. 6, p. 1450-1454. DOI
Yoon, Soon-Seek., Byun, Jae-Won., Kim, Min-Jeong., Bae, You-Chan., Shin, Yeun-Kyung., Yoon, Sorah., Lee, Garam., Song, Jae-Young. Natural Occurrence of Grape Poisoning in Two Dogs. Journal of veterinary medical science, 2011, vol. 73, no. 2, p. 275-277. DOI
Yamakoshi, J., Saito, M., Kataoka, S., Kikuchi, M. Safety evaluation of proanthocyanidin-rich extract from grape seeds. Food and chemical toxicology, 2002, vol. 40, no. 5, p. 599-607. DOI
Stagos, Dimitrios., Spanou, Chrysa., Margariti, Maria., Stathopoulos, Constantinos., Mamuris, Zissis., Kazantzoglou, Georgios., Magiatis, Prokopios., Kouretas, Demetrios. Cytogenetic effects of grape extracts (Vitis vinifera) and polyphenols on mitomycin C-induced sister chromatid exchanges (SCEs) in human blood lymphocytes . Journal of agricultural and food chemistry, 2007, vol. 55, no. 13, p. 5246-5252. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature