Botanical species · safety record

Voacanga africana

The EFSA Compendium of Botanicals holds 11 constituent measurements and 1 adverse-effect record for Voacanga africana. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Voacanga africana Stapf

11Constituent measurements

1Safety records

11Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Bark	—	—	Chromatographic tests	Resolve DOI
Alkaloids	Bark	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Alkaloids	Seed	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Alkaloids	Seed	Solvent extraction	—	—	Resolve DOI
Ibogaine	Seed	Solvent extraction	—	—	Resolve DOI
Indole alkaloids	Bark	Solvent extraction	—	Element spectroscopy	Resolve DOI
Indole alkaloids	Bark	Solvent extraction	—	Chromatographic tests	Resolve DOI
Voacangine	Bark	Solvent extraction	9.71 Percent	HPLC-DAD	Resolve DOI
Alkaloids	Fruit unspecified	—	—	Unspecified	No resolvable identifier
Alkaloids	Seed	Solvent extraction	10 Percent	Mass Spectroscopy and hyphenated methods without chromatography	No resolvable identifier
Voaphylline	Leaves	—	—	Mass Spectroscopy and hyphenated methods without chromatography	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Other toxicities	—	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Puisieux, Francis., Devissaguet, Jean P., Miet, Christine., Poisson, Jacques. Alkaloids of Voacanga. V. Voacamine N-oxide. Bulletin de la societe chimique de france, 1967, vol. (1), p. 251-3.
Kunesch, Nicole., Das, Bhupeshchandra., Poisson, Jacques. Voacanga alkaloids. IX. Voaphylline hydroxy-indolenine, a new alkaloid extracted from the leaves of Voacanga africana. Bulletin de la societe chimique de france, 1967, vol. (9), p. 3551-2.
Mair, Christina E., Silva, Carolina de Miranda., Grienke, Ulrike., Kratz, Jadel M., Carreno, Fernando., Zimmermann, Estevan Sonego., de Araujo, Bibiana Verlindo., Costa, Teresa Dalla., Rollinger, Judith M. Pharmacokinetics of hERG Channel Blocking Voacangine in Wistar Rats Applying a Validated LC-ESI-MS/MS Method . Planta medica, 2016, vol. 82, no. 11-12, p. 1030-1038. DOI
Kitajima, Mariko., Iwai, Masumi., Kikura-Hanajiri, Ruri., Goda, Yukihiro., Iida, Mitsuru., Yabushita, Hisatoshi., Takayama, Hiromitsu. Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity . Bioorganic & medicinal chemistry letters, 2011, vol. 21, no. 7, p. 1962-1964. DOI
Chen, Hong-Mei., Yang, Yu-Ting., Li, Hong-Xiang., Cao, Zhi-Xing., Dan, Xiao-Mei., Mei, Ling., Guo, Da-Le., Song, Chuan-Xia., Dai, Yu., Hu, Jia., Deng, Yun. Cytotoxic monoterpenoid indole alkaloids isolated from the barks of Voacanga africana Staph. . Natural product research, 2016, vol. 30, no. 10, p. 1144-1149. DOI
Kombian, SB., Saleh, TM., Fiagbe, NIY., Chen, XH., Akabutu, JJ., Buolamwini, JK., Pittman, QJ. Ibogaine and a total alkaloidal extract of Voacanga africana modulate neuronal excitability and synaptic transmission in the rat parabrachial nucleus in vitro . Brain research bulletin, 1997, vol. 44, no. 5, p. 603-610. DOI
Ighodaro, Igbe., Silvanus, Innih., Stephen, Vincent Ogedengbe., Lucy, Amamina. Chronic toxicity studies of aqueous leaf extract of Voacanga africana in wistar rats. Journal of applied sciences and environmental management, 2015, vol. 19, no. 4, p. 639-646.
THOMAS, DW., BIEMANN, K. HYDROXYINDOLENINE DERIVATIVE OF VOACANGINE A NEW INDOLE ALKALOID FROM VOACANGA AFRICANA . Tetrahedron, 1968, vol. 24, no. 11, p. 4223-&. DOI
Boda, M., Tan, P.V., Nyasse, B. Rapid in vivo screening method for the evaluation of new anti Helicobacter medicinal preparations. African journal of traditional, complementary and alternative medicines, 2006, vol. 3, no. 4, p. 102-114.
Posch, Tjorben Nils., Martin, Nathalie., Puetz, Michael., Huhn, Carolin. Nonaqueous capillary Electrophoresis-mass spectrometry: A versatile, straightforward tool for the analysis of alkaloids from psychoactive plant extracts. Electrophoresis, 2012, vol. 33, no. 11, p. 1557-1566.
Kitajima, Mariko., Iwai, Masumi., Kogure, Noriyuki., Kikura-Hanajiri, Ruri., Goda, Yukihiro., Takayama, Hiromitsu. Aspidosperma-aspidosperma-type bisindole alkaloids from Voacanga africana . Tetrahedron, 2013, vol. 69, no. 2, p. 796-801. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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