Botanical species · safety record
Zingiber officinale
The EFSA Compendium of Botanicals holds 11 genotoxicity assays for Zingiber officinale. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Zingiber officinale Roscoe
Regulatory presence
Health Canada's Licensed Natural Health Products Database holds 5,145 licensed products naming Zingiber officinale as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.
Extract types on licence
Source material stated
Genotoxicity testing
Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.
| Outcome | Endpoint | Test | Tested organism | Metabolic activation | Source |
|---|---|---|---|---|---|
| Positive | DNA damage and/or repair | single cell gel/comet assay in mammalian cells for detection of DNA damage | Other | Not applicable | Resolve DOI |
| Positive | gene mutation | bacterial reverse mutation assay | Salmonella typhimurium (as organism) | Without | Resolve DOI |
| Positive | gene mutation | bacterial reverse mutation assay | Salmonella typhimurium (as organism) | Without | Resolve DOI |
| Positive | gene mutation | bacterial reverse mutation assay | Salmonella typhimurium (as organism) | With and without | Resolve DOI |
| Positive | chromosome aberration | sister chromatid exchange assay in mammalian cells | Other | Not applicable | No resolvable identifier |
| Positive | gene mutation | bacterial reverse mutation assay | Salmonella typhimurium (as organism) | With | No resolvable identifier |
| Positive | gene mutation | bacterial reverse mutation assay | Salmonella typhimurium (as organism) | With | No resolvable identifier |
| Positive | gene mutation | bacterial reverse mutation assay | Salmonella typhimurium (as organism) | With | No resolvable identifier |
| Positive | gene mutation | bacterial reverse mutation assay | Salmonella typhimurium (as organism) | With | No resolvable identifier |
| Positive | gene mutation | bacterial reverse mutation assay | Salmonella typhimurium (as organism) | With | No resolvable identifier |
| Positive | gene mutation | bacterial reverse mutation assay | Salmonella typhimurium (as organism) | With | No resolvable identifier |
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- Mahmoud, I., Alkofahi, A., Abdelaziz, A. Mutagenic and toxic activities of several spices and some jordanian medicinal plants. Pharmaceutical biology, 1992, vol. 30, no. 2, p. 81-85. DOI
- Yang, Guang., Zhong, Laifu., Jiang, Liping., Geng, Chengyan., Cao, Jun., Sun, Xiance., Ma, Yufang. Genotoxic effect of 6-gingerol on human hepatoma G2 cells. Chemico-biological interactions, 2010, vol. 185, no. 1, p. 12-17. DOI
- Ratanavalachai, Treetip., Thitiorul, Sumon., Tanuchit, Sermkiat., Jenkhetkan, Wantha., Itharat, Arunporn., Sakpakdeejaroen, Intouch. Synergistic Genotoxic Effects and Modulation of Cell Cycle by Ginger Ethanolic Extracts in Adjunct to Doxorubicin in Human Lymphocytes In Vitro. . Journal of the medical association of thailand = chotmaihet thangphaet, 2015, vol. 98 Suppl 3, p. S101-9.
- Nagabhushan, M., Amonkar, A. J., Bhide, S. V. Mutagenicity of gingerol and shogaol and antimutagenicity of zingerone in Salmonella/microsome assay. Cancer letters (shannon, ireland), 1987, p. 221-233.
- Abudayyak, Mahmoud., Ozdemir Nath, Ebru., Ozhan, Gul. Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey. TURKISH JOURNAL OF MEDICAL SCIENCES, 2015, vol. 45, no. 3, p. 496-506. DOI
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
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